Figure 2.
The combination therapy of curcumin and thioridazine for resistant human head and neck squamous cell carcinoma (AMC-HN4). (A) A scheme showing that the combination therapy downregulated the expression of c-FLIP and Mcl-1 via NOX4-mediated ROS production for restoring apoptosis. The synergistically induced (B) apoptosis and (C) ROS production by curcumin and thioridazine in AMC-HN4 cells. (D) The downregulation of c-FLIP and Mcl-1 induced by the combination therapy in NOX4-dependent manner. Reproduced from 87 with permission from Elsevier.