Figure 7.

SMURF2 depletion promotes the formation and development of xenograft tumors. (A) Tumor volumes were measured and calculated every two days between SMURF2-NC and SMURF2-KD groups. (B) Images of tumor-bearing mice were captured from SMURF2-NC and SMURF2-KD groups. (C) Representative images of tumors obtained from SMURF2-NC and SMURF2-KD groups. (D) Tumor weight was assessed at the end time points the experiments. (E) Typical immunohistochemical images of tumor tissues exhibited the expression of SMURF2, ID2 and p21. ^*P < 0.05; ^**P < 0.01; ^***P < 0.001; ^****P < 0.0001.