Table 2.

Physiological functions and causes of abnormal expression patterns of potential protein targets in various diseases.

Target protein	Physiological function	Abnormal expression	Disease
KRAS	Signal transduction	Mutation	Pancreatic cancer, colorectal cancer, non-small cell lung cancer, etc.
p53	Transcription	Mutation	Lung cancer, stomach cancer, liver cancer, etc.
C-MYC	Transcription	Overexpression	Lung cancer, stomach cancer, breast cancer, etc.
STAT3	Transcription	Overexpression	Rectal cancer, lung cancer, breast cancer, etc.
AR-V7	Transcription	Overexpression	Metastatic castration-resistant prostate cancer
β-catenin	Transcription	Abnormal accumulation	Colon cancer, hepatocellular carcinoma, pancreatic cancer, etc.
HOXA9	Transcription	Overexpression	Acute myeloid leukemia
MEIS1	Transcription	Overexpression	Acute myeloid leukemia
EWS-FLI1	/	Fusion	Ewing sarcoma
PTP	Post-translation modification	Elevated/reduced expression	Breast cancer, stomach cancer, prostate cancer, rheumatoid arthritis, systemic lupus erythematosus, etc.
HAT	Post-translation modification	Mutation	Leukemogenesis, Rubinstein-Taybi syndrome, etc.
SMARCA2	Chromatin remodelling	/	Non-small cell lung cancer, etc.