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p53 governs MDM2 inhibitor effects on Bcl2/Bax ratio and PTEN-deficient CRC cell death. A, C Immunoblot showing Bax and Bcl2 protein expression in HCT116 and RKO PTEN-/- cells upon p53 silencing with or without MDM2 inhibitor (CGM097) treatment. B, D. Viability analysis in p53 knockdown HCT116 and RKO PTEN-/- cells after CGM097 treatment. Data are presented as mean ± SD (n = 3 independent experiments), **P < 0.01 between two indicated bars (t test).
