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. 2023 Jul 3;19(11):3428–3440. doi: 10.7150/ijbs.84426

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Excessive mitochondrial fission activates the mtDNA/STING/p65 pathway in cardiomyocytes. (A-D) RT-qPCR was used to analyze the transcription of TFAM, TRMT10C, ELAC2, and FASTKD2 in cytosolic extracts from heart tissues. (E-H) Transcriptional analysis of TFAM, TRMT10C, ELAC2, and FASTKD2 expression in cytosolic fractions from HL-1 cells. (I-L) Western blot analysis of cGAS and STING expression and p65 phosphorylation in HL-1 cells. (M, N) Immunofluorescence detection of phosphorylated p65 in HL-1 cells. Mdivi-1 was used to inhibit mitochondrial fission before hypoxia treatment. #p<0.05.