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. 2023 Jul 23;45(1):2238831. doi: 10.1080/0886022X.2023.2238831

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© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 5. — COS administration attenuates renal interstitial fibrosis at 2 months after renal I/R injury. (A) Renal morphology was examined with H&E staining. Areas bordered by yellow dotted line shows the pathological changes in kidney. Scale bar represents 50 μm. (B) Renal interstitial fibrosis was detected using Masson trichome staining. Arrows show extracellular matrix deposition around renal tubules. Scale bar represents 50 μm. (C) Immunohistochemical staining of α-SMA. Scale bar represents 50 μm. (D) IHC analysis of Collagen I in kidney tissues. Scale bar represents 50 μm. (E-F) mRNA expression of Collagen I and Fibronectin relative to GAPDH (mean ± SEM, *p < 0.05, n = 8).