Table 2.

The association of being uninfected with RSV in infancy with the primary and secondary outcomes.^*†

Outcome	Unadjusted analyses			Adjusted analyses ‡
	N° of children with outcome / total n° of children included in statistical analyses (%)	Estimate (95% CI)	p-value	N° of children with outcome / total n° of children included in statistical analyses (%)	Estimate (95% CI)	p-value
Primary outcome
Five-year current asthma	230/1,257 (18.30%)	0.75 (0.59–0.95)	0.02	224/1,237 (18.11%)	0.74 (0.58–0.94)	0.01
Secondary outcomes
Recurrent wheeze
One-year	250/1,705 (14.66%)	0.51 (0.40–0.65)	<0.001	239/1,687 (14.17%)	0.54 (0.42–0.70)	<0.001
Two-year	244/1,630 (14.97%)	0.73 (0.57–0.92)	0.009	234/1,603 (14.60%)	0.78 (0.61–0.99)	0.04
Three-year	191/1,416 (13.49%)	0.81 (0.62–1.05)	0.11	185/1,393(13.81%)	0.81 (0.61–1.06)	0.12
Four-year	166/1,455 (11.41%)	0.82 (0.61–1.09)	0.18	162/1,434 (11.30%)	0.85 (0.63–1.13)	0.26
5-year current asthma inflammatory subtype - Definition 1§
None	1,027/1,217 (84.39%)	Reference		1,013/1,197 (84.63%)	Reference
Non-atopic	91/1,217 (7.48%)	0.55 (0.35–0.87)	0.01	89/1197 (7.44%)	0.55 (0.35–0.86)	0.01
Atopic	99/1,217 (8.13%)	0.93 (0.61–1.41)	0.73	95/1197 (7.94%)	0.89 (0.58–1.36)	0.59
5-year current asthma inflammatory subtype - Definition 2§
None	1,027/1,254 (81.90%)	Reference		1,013/1,234 (82.09%)	Reference
Non-atopic	86/1,254 (6.86%)	0.84 (0.59–1.20)	0.006	81/1,234 (6.56%)	0.48 (0.30–0.78)	0.003
Atopic	141/1,254 (11.24%)	0.84 (0.59–1.20)	0.34	140/1,234 (11.35%)	0.83 (0.58–1.20)	0.33

Definition of abbreviations: CI = Confidence interval, RSV = Respiratory syncytial virus.

^*For the outcomes of 5-year current asthma and recurrent wheeze at each of the measured time points, the estimates presented are risk ratios obtained from modified Poisson regression models. For the outcome of 5-year current asthma inflammatory subtype, the estimates presented are odds ratios from multinomial logistic regression models. For all models, the reference group included children infected with RSV in infancy.

^†The statistical analyses were conducted in children with complete data.

^‡The adjusted models included child’s sex, race and ethnicity, ever breastfeeding, daycare attendance in infancy, exposure to secondhand smoking in utero or in early infancy, and maternal asthma as covariates.

^§For definition 1 of 5-year current asthma inflammatory subtype, atopy was ascertained using evidence of aeroallergen sensitization by skin prick testing or blood specific IgE testing at age 3 years. For definition 2 of 5-year current asthma inflammatory subtype, atopy was ascertained by parental report of ever physician-diagnosed allergic rhinitis or atopic dermatitis at age 5 years.