Table 1.
Regulation of TCM and its bioactive compounds on lipid metabolism
Bioactive compounds | Chinese herbs | Cancer cells | Potential mechanisms | Ref. |
---|---|---|---|---|
GL22 | Ganoderma leucocontextum | Liver cancer cells | Decreasing the expression of FABPs | 84 |
/ | GT | Prostate cancer cells | Inhibiting the expression of SREBP-1 | 85 |
Oridonin | Rabdosia rubescen | Colorectal cancer cells | Inhibiting the expression of SREBP-1 | 86 |
/ | Zhiheshouwu | HCC cells | Inhibiting SREBP-1 and its downstream factor SCD1 | 87 |
/ | Quercetin | HCC cells | Inhibiting FASN activity and downregulating FASN expression | 88 |
Osthole | Cnidium monnieri (L.) Cusson | Breast cancer cells | Inhibiting FASN expression | 89 |
DMC | Rhizomes of turmeric | TNBC cells | Inhibiting FASN expression | 90 |
Emodin | / | HCC cells | Regulating the transcriptional activity of SREBP-2 | 91 |
Protopanaxadiol | Ginseng | Colorectal cancer cells | Inhibiting the expression of FASN and ACAT-2 | 92 |
BME | Bitter melon | TNBC cells | Inhibiting ACAT-1 expression | 93 |
MAP30 | Bitter melon | Ovarian cancer cells | Reducing GLUT-1/3 expression | 94 |
acRoots extract | acRoots | HCC cells | Reducing LDL uptake and intracellular cholesterol levels | 95 |