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. 2023 Jul 9;14(11):2066–2074. doi: 10.7150/jca.86683

Table 1.

Regulation of TCM and its bioactive compounds on lipid metabolism

Bioactive compounds Chinese herbs Cancer cells Potential mechanisms Ref.
GL22 Ganoderma leucocontextum Liver cancer cells Decreasing the expression of FABPs 84
/ GT Prostate cancer cells Inhibiting the expression of SREBP-1 85
Oridonin Rabdosia rubescen Colorectal cancer cells Inhibiting the expression of SREBP-1 86
/ Zhiheshouwu HCC cells Inhibiting SREBP-1 and its downstream factor SCD1 87
/ Quercetin HCC cells Inhibiting FASN activity and downregulating FASN expression 88
Osthole Cnidium monnieri (L.) Cusson Breast cancer cells Inhibiting FASN expression 89
DMC Rhizomes of turmeric TNBC cells Inhibiting FASN expression 90
Emodin / HCC cells Regulating the transcriptional activity of SREBP-2 91
Protopanaxadiol Ginseng Colorectal cancer cells Inhibiting the expression of FASN and ACAT-2 92
BME Bitter melon TNBC cells Inhibiting ACAT-1 expression 93
MAP30 Bitter melon Ovarian cancer cells Reducing GLUT-1/3 expression 94
acRoots extract acRoots HCC cells Reducing LDL uptake and intracellular cholesterol levels 95