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. 2023 Jul 3;14(11):1946–1955. doi: 10.7150/jca.84170

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ER stress activates TAp73α through the PERK pathway. (A) HCT116^p53-/- cells were treated with or without ER stress inducers for 24 h and then subjected to qPCR analysis. (B) HCT116^p53-/- cells stably expressing shC, shPERK, shATF6α or shIRE1α were subjected to western blotting. (C) HCT116^p53-/- cells stably expressing shC or shPERK were subjected to qPCR analysis. (D-E) HCT116^p53-/- cells stably expressing empty vector (EV) or PERK were subjected to western blot analysis (D) and qPCR analysis (E). The results are presented as the mean ± SD of three independent experiments; **P<0.01.