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Activation of ER stress inhibits colorectal cancer growth and promotes apoptosis in vivo. (A) Colon cancer PDX model mice were treated with or without TM (0.25 mg/kg, 3 times a week) for three weeks. Tumors were harvested for imaging, and measurement of volume (B) and weight (C) and were then embedded in paraffin for IHC analysis (D). (E) A working model showing that ER stress activates TAp73α via PERK-ATF4 signalling to promote apoptosis.
