Table 1.

miRNAs derived from exosomes associated with chemoresistance in ovarian cancer

miRNAs in ovarian cancer	Pathways	The role of miRNAs in promoting chemoresistance in ovarian cancer.	Reference
miR-21	Apoptosis associated pathways	Bind with the APAF1 target to induce paclitaxel resistance in OVCA432 and SKOV3 cells.	27
miR-21-3p		Expression of miR-21-3p was 50-fold higher level in the A2780 cells and CP70 cells by suppressing the expression of NAV3.	41
miR-433		Induce cellular senescence by downregulating cyclin-dependent kinase6.	42
miR-484	Angiogenesis	Targeting RGD-modified exosomes inhibits tumor angiogenesis and increases sensitivity.	64
miR-21-5p	Increased glycolysis by miR-21-5p/PDHA1 axis	Increased glycolysis by upregulating PDHA1 exosomal miR-21-5p derived from DDP-resistant SKOV3 cells.	65
miR-429	Targeting CASR/STAT3 pathway	Induced DDP resistance targeting the CASR/STAT3 pathway in A2780 cells and xenograft mice tumors	66
miR-223	Targeting PTEN-PI3K/AKT pathways	Exosomal miR-223 derived from macrophages promoted drug resistance via the PTEN-PI3K/AKT pathway in SKOV3 cells and SKOV3 xenograft models.	67