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. 2023 Jul 9;14(11):2075–2084. doi: 10.7150/jca.86304

Figure 1.

Figure 1

Chemical screening of P. tuberaster mycelium culture extracts for antitumor activity. (A) Four extracts were produced from P. tuberaster mycelium grown in four distinct culture media (DYB, MEB, MYB and PDB). Hela cells were treated with each extract at a dose of 0.1 mg/ml. The cell proliferation inhibitory effect was evaluated on the 4th day of treatment. Paclitaxel was used as a positive control group. Student t-test, **P < 0.01, student t-test. Means ± S.D., n = 10. (B) Determining pt-PDB's cytotoxicity. Cell viability was assessed by measuring cell proliferation at 0.1-0.5 mg/ml pt-PDB concentrations and comparing the results to those in DMSO. Means ± S.D., n = 10. R2 (coefficient of determination) = 0.9241. (C) Determining pt-PDB's optimal concentration to inhibit cell proliferation. Cell proliferation was assessed 1, 2, 3 and 4 days after treatment at concentrations of 0.02 to 0.1 mg/ml. *P < 0.05, **P < 0.01, student t-test. Means ± S.D., n = 10.