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. 2023 Jul 9;14(11):2109–2127. doi: 10.7150/jca.85778

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CALB2 promoted invasion and migration of CRC. (A) Representative immunohistochemical images of CALB2 in stage I/II and stage III/IV CRC tissues. Scale bar: 50um. (B) The expressions of CALB2 in stage III/IV CRC tissues were higher than those in stage I/II CRC tissues. (C) Transwell migration and invasion assays showed that CALB2 overexpression significantly promoted migration and invasion of DLD-1 and SW480 cells. The number of migratory and invasive cells were counted and plotted. (D) Wound-healing assay showed that CALB2 overexpression promoted wound area recovery. The wound area was measured and plotted. (E) CALB2 overexpression promoted upregulation of MMP9 and downregulation of E-cadherin as shown by western blot analysis.VE: Vehicle control; OE: Overexpression. * P < 0.05, ** P < 0.01, *** P < 0.001.