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Fig. 1. (a) Chemical structures of positively charged M4SURF (1), the neutral PFPE–PEG–PFPE type fluorosurfactant PICO-SURF (2) and negatively charged KRYTOX (3). (b) Schematic illustration of the 4-component Ugi reaction to synthesize M4SURF. Details of the synthesis can be found in the Experimental section and in Fig. S1 in the ESI,† which also includes a discussion on the efficiency and sustainability of the multicomponent Ugi reaction.