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Fig. 2. Molecular illustrations of cationic lipids. The permanently cationic lipids (A) DOTMA (1,2-di-O-octadecenyl-3-trimethylammonium propane) and (B) DOTAP (18:1 TAP) and the ionizable cationic lipids (C) Dlin-KC2-DMA and (D) Dlin-MC3-DMA are the most commonly used lipids for lipid nanoparticles.