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. 2023 Jul 7;5(15):3834–3856. doi: 10.1039/d3na00198a

Direct conjugation of ligands to lipids.

Receptors Targeting ligands Targeting strategy Diseases Reference
Monocytes in bone marrow Bisphosphonate Alendronate-bearing ionizable lipid (one-pot assembly) X, bone targeting 64
Bone marrow mesenchymal stem cells Bone homing peptide Ionizable lipid having a head group of BHODA (or HODA or ODA) (one-pot assembly) Osteoporosis 97
Langerhans cells, dermal DCs, and resident DCs in the skin-draining lymph node Mannose (intradermal) Man-cholesterolamine Influenza virus 65
LSEC Mannose DSPE-PEG-mannose and then ApoE mixing X, liver targeting 66
CD209/DC-SIGN and CD207/Langerin (human and mouse DCs and other hematopoietic cell populations) Mannose TriMN-Lip, MN-Lip, 1-O-carboxyl-2-O-phytanyl-3-O-hexadecane-sn-glycerol, the O,O-dioleyl-N-[3N-(N-methylimidazolium iodide)propylene] phosphoramidate, O,O-dioleyl-N-histamine phosphoramidate, and PEG-HpK Tumor 98
Invariant natural killer T cells α-Galactosylceramide α-Galactosylceramide (replacement) Tumor (melanoma) 99
Dendritic cells in a lymph node after SC Mannose PEG-mannose Tumor (melanoma) 100
Dendritic cells Mannose analogues Mannose analogues Tumor (melanoma) 101
Dendritic cell Mannose PEG-HpK and TriManlipo100 Tumor (melanoma) 103