| B lymphocytes in the spleen |
EDC coupling |
OF-Deg-Lin |
X |
67
|
| T lymphocytes in the spleen |
EDC coupling |
11-A-M (constrained) |
X |
68
|
| Albumin associated micropinocytosis and endocytosis |
EDCI |
Alkyne (unsaturated) and ester groups into the lipid tails of Dlin-MC3-DMA |
X |
89
|
| Macrophages containing antimicrobial peptides linked to cathepsin B in the lysosomes (MACs) |
NaBH(OAc)3
|
Vitamin C |
Sepsis |
70
|
| Spleen |
NABH4
|
tB-UC18 [3,5-bis-(1-octadec-9-enylamino-methyl)-benzyl]-octadec-9-enyl-amine |
X |
87
|
| Unsaturation |
| Liver |
Sequential |
Unsaturated thiol conjugated lipids promote endosomal escape |
X |
88
|
| Synthesis |
| STING pathway immune cells |
Amine/isocyanide/ketone of 1 : 1 : 1 |
Unsaturated lipid tail, a dihydroimidazole linker and cyclic amine head groups containing lipids (activation of the STING pathway) |
Tumor (melanoma and HPV E7) |
69
|
| Lung |
Michael addition reaction (amine and acrylate) |
Lipids containing an amide bond in the tail |
Tuberous sclerosis complex |
71
|
| Fetal liver |
Michael addition (the polyamine cores and lipid epoxide) |
Polyamines with epoxide terminated alkyl tails |
X |
72
|
| APCs in lymph nodes |
Michael addition (amine-bearing head and an acryloyl group containing aliphatic chain) |
Combination of lipids |
Melanoma |
90
|
