Helper lipid modification.
| Type of lipid modified | Target organ/cells | Chemical synthesis strategy | Targeting strategy | Diseases | Reference |
|---|---|---|---|---|---|
| Cholesterol | Hepatic endothelial cells | Amine epoxide | Esterified cholesterol | X | 73 |
| Cholesterol | Liver microenvironment cells (hepatic endothelial cells and Kupffer cells) | Pyridine | Oxidized cholesterol | X | 74 |
| Phospholipid | Secondary lymphoid organs | X | Phosphatidyl serine | X | 75 |
| Phospholipid | Liver ECs and Kupffer cells | EDCI DMAP | Phospholipid containing an adamantyl group (constrained) | X | 76 |
| PEG lipid | Bone marrow endothelial cells (BMECs) | Amine epoxide | Alkyl-tailed PEG | X | 77 |