Skip to main content
. 2023 Jul 7;5(15):3834–3856. doi: 10.1039/d3na00198a

Various charged lipids.

Charge of the lipid Target organ/cells Chemical synthesis strategy Targeting strategy Diseases Reference
Anionic Spleen and liver X Helper lipids X 91
Anionic Lymph node X Cholesteryl hemisuccinate (CHEMS) X 78
Permanently cationic αvβ3-expressed cells X 18:1 TAP (DOTAP) Tumor (melanoma and hepatocellular carcinoma) 79
Permanently cationic APCs in the spleen X DODAP X 92
Zwitterionic, ionizable cationic, and permanently cationic Liver X Mixture of lipids (DOTAP, DDAB, DOPE, DSPC, 14PA, and 18PG) X 93
Zwitterionic, ionizable cationic, and permanently cationic (respectively) Spleen, liver, and lungs (respectively) X Synthetic iPhos X 94
Anionic, neutral, and cationic (respectively) Spleen, liver, and lungs (respectively) X Anionic lipids (18PA, 14PA and 18BMP) and DOTAP X 95