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. 2023 Jul 7;5(15):3834–3856. doi: 10.1039/d3na00198a

The targeting strategies: pre-modification of CDNs.

The strategy of manipulation Target organ/cells Ligand Disease Reference
Glycometabolic Blood vessels DSPE-PEG-RGD (Arg–Gly–Asp) X 187
Genetic Neurons, microglia and oligodendrocytes in the brain RVG (Rabies Virus Glycoprotein)-Lamp2b (lysosome-associated membrane protein 2b) Alzheimer's disease 189
Genetic Brain RVG (Rabies Virus Glycoprotein)-Lamp2b (lysosome-associated membrane protein 2b) Ischemic stroke 190
Genetic Chronic myelogenous leukemia (CML) cells Fragment of interlukin 3 (IL-3) Acute myeloid leukemia 191
Genetic B lymphocytes CD 19 chimeric antigen receptor Hematological malignant diseases 193
Genetic Liver cancer cells Pre S1 as a targeting moiety for sodium taurocholate cotransporting polypeptide (NTCP) Liver cancer 194
Glycometabolic Activated macrophages (M1) Dextran sulfate (DS) as a targeting moiety for macrophage scavenger receptor class A (SR-A) Rheumatoid arthritis 196
Glycometabolic 4T1 CD 47 Breast cancer 197