| Succinimidyl-[(N-maleimidopropionamido)-polyethyleneglycol] ester (NHS-PEG-maleimide) is used as a hinge that anchors the ligands |
PC3 cells |
Recombinant human hyaluronidase, PH20 (rHuPH20) |
Cancer having a pericellular HA matrix |
205
|
| DNA is engineered to be a hinge that anchors the ligands |
A549 and MCF 7 cells |
Quantum dots (QDs) |
Lung cancer and breast cancer |
206
|
| Thiol–maleimide is used as a hinge that anchors the ligands |
HepG2 cells |
Antibody against a transferrin receptor (TfR) |
Hepatocellular carcinoma |
207
|
| DSPE-PEG-maleimide is used as a hinge that anchors the ligands |
MCF 7 cells |
FITC for fluorescent imaging |
Breast cancer |
208
|
| Dibenzocyclooctyne (DBCO)–azide cycloaddition |
Integrin αvβ3 in reactive cerebral vascular endothelial cells |
c(RGDyK) peptide |
Cerebral ischemia |
209
|
| Copper-catalyzed azide alkyne cycloaddition |
4t1 cells |
4t1 exosomal proteins |
Breast cancer |
210
|
| Supplementing the membrane with additional cholesterol, stabilizing the nanostructure and facilitating the retention of a pH gradient |
4t1 cells |
No ligand |
Breast cancer |
203
|
| Phospholipid insertion to anchor the epidermal growth factor receptor (EGFR) binding nanobodies |
EGFR-overexpressing tumor cells |
EGFR |
X |
211
|
| Tetrahedral DNA structures that are conjugated with a DNA aptamer are tethered in CDNs using cholesterol anchoring |
HepG2 cells |
TLS11a aptamers |
Hepatocellular carcinoma |
212
|
| ChiP in DMSO was mixed with exosomes in PBS, and the mixture was shocked in an ice bath (hydrophobic aggregation was used) |
|
A multifunctional chimeric peptide |
|
213
|
| The positive charge from the multifunctional peptide could electrostatically interact with the negative charge of the CDNs |
HepG2 cells |
Pullulan |
Hepatocellular carcinoma |
214
|
