Table 2.
Single- and repeated-dose PK data for vitamin D metabolites
| Treatment | Day 1 dose | Day 29 dose | ||||
|---|---|---|---|---|---|---|
| Baseline | C max | % change | Baseline | C max | % change | |
| Changes in serum 25OHD, ng/mL | ||||||
| ERC | 22.7 | 24.1 | 6.3 | 63.1 | 65.5 | 3.8 |
| IRC | 23.3 | 39.3 | 68.8 | 27.0 | 42.4 | 57.1 |
| HDC | 19.3 | 29.5 | 53.2 | 29.4 | 37.7 | 28.2 |
| PLDC | 19.0 | 23.6 | 24.2 | 21.9 | 22.7 | 3.9 |
| Changes in serum 1,25(OH)2D or serum paricalcitol, pg/mL | ||||||
| ERC | 29.0 | 32.5 | 12.4 | 50.4 | 54.1 | 7.2 |
| IRC | 27.2 | 39.7 | 46.3 | 32.1 | 43.7 | 36.0 |
| HDC | 23.9 | 36.7 | 53.1 | 30.2 | 34.7 | 14.8 |
| PLDC | ND | 19.9 | NC | 19.6 | 51.5 | 262.8 |
| Changes in serum 24,25(OH)2D₃, ng/mL | ||||||
| ERC | 0.923 | 0.923 | 0.0 | 2.878 | 2.953 | 2.6 |
| IRC | 0.991 | 1.168 | 17.8 | 1.085 | 1.307 | 20.5 |
| HDC | 0.954 | 1.008 | 5.6 | 1.264 | 1.349 | 6.8 |
| PLDC | 0.793 | 0.852 | 7.4 | 0.895 | 0.897 | 0.0 |
| ND = not detected | ||||||
| NC = not calculated | ||||||