Table 4.
Cumulative survival according to the AJCC 8th and ECOG E8811 trial definitions of macroscopic and microscopic ENE.
| Microscopic ENE (≤2 mm) | Macroscopic ENE (>2 mm) | P values | |||||
|---|---|---|---|---|---|---|---|
| No vs. microscopic ENE | No vs. macroscopic ENE | Microscopic macroscopic vs. ENE | |||||
| 5-year | 10-year | 5-year | 10-year | ||||
| OS | 70% | 50% | 61% | 45% | <0.001 | <0.001 | 0.484 |
| DSS | 83% | 83% | 67% | 67% | 0.024 | <0.001 | 0.260 |
| DFS | 76% | 76% | 60% | 60% | 0.148 | <0.001 | 0.229 |
| DMFS | 91% | 91% | 76% | 76% | 0.799 | 0.003 | 0.230 |
| RRFS | 84% | 84% | 83% | 83% | 0.040 | 0.011 | 0.960 |
| LRFS | 100% | 100% | 83% | 83% | 0.517 | 0.018 | 0.147 |
| Microscopic ENE (≤1 mm) | Macroscopic ENE (>1 mm) | ||||||
| OS | 79% | 59% | 60% | 48% | 0.023 | <0.001 | 0.562 |
| DSS | 88% | 88% | 66% | 66% | 0.157 | <0.001 | 0.454 |
| DFS | 73% | 73% | 67% | 67% | 0.195 | <0.001 | 0.587 |
| DMFS | 82% | 82% | 83% | 83% | 0.470 | 0.011 | 0.684 |
| RRFS | 89% | 89% | 86% | 86% | 0.226 | 0.005 | 0.928 |
| LRFS | 100% | 100% | 88% | 88% | 0.580 | 0.038 | 0.351 |
OS overall survival, DSS disease specific survival, RFS recurrence free survival, DMFS distant metastasis free survival, RRFS regional recurrence free survival, LRFS local recurrence free survival.
P values were obtained using log rank test. Bold P values are significant P values. Irregular soft tissue deposit is considered as macroscopic ENE.