TABLE 2.
Antimalarial effects of ivermectin in combination with antimalarial drugs on asexual blood stages of P. falciparuma
| Drug combination(Drug A – Drug B) | Artemisinin-sensitive isolates (n = 2; NF54, ARN3G) |
Artemisinin-resistant isolates (n = 3; APL5G, APS2G, ARN2G) |
||||
|---|---|---|---|---|---|---|
| IC50 of ivermectin, (x103 nM) | IC50 of antimalarial, nM | ∑FIC | IC50 of ivermectin, (x103 nM) | IC50 of antimalarial, nM | ∑FIC | |
| Ivermectin – Amodiaquine | 0.94(0.72 to 1.16) | 11.42(7.94 to 14.90) | 1.18(1.09 to 1.27) | 1.18(0.82 to 1.53) | 12.31(10.83 to 13.79) | 1.21(1.13 to 1.30) |
| Ivermectin – Artesunate | 0.93(0.77 to 1.10) | 3.07(0.72 to 5.41) | 1.31(1.18 to 1.44) | 1.27(0.98 to 1.56) | 3.90(2.24 to 5.57) | 1.16(1.06 to 1.26) |
| Ivermectin – Atovaquone | 0.79(0.70 to 0.88) | 0.38(0.25 to 0.51) | 0.89(0.73 to 1.06) | 1.20(0.81 to 1.58) | 0.62(0.21 to 1.04) | 0.90(0.77 to 1.02) |
| Ivermectin – Dihydroartemisinin | 1.07(0.83 to 1.32) | 1.93(1.40 to 2.47) | 1.15(1.10 to 1.19) | 1.30(1.16 to 1.45) | 1.92(1.77 to 2.06) | 1.15(1.09 to 1.21) |
| Ivermectin – Lumefantrine | 0.95(0.70 to 1.19) | 7.40(2.11 to 12.70) | 1.13(1.03 to 1.22) | 1.41(0.99 to 1.83) | 6.14(3.96 to 8.32) | 1.09(0.98 to 1.21) |
| Ivermectin – Mefloquine | 0.78(0.62 to 0.93) | 10.96(4.05 to 17.87) | 1.15(1.03 to 1.27) | 1.13(0.92 to 1.27) | 23.08(10.2 to 35.97) | 1.14(1.02 to 1.25) |
| Ivermectin – Piperaquine | 0.80(0.66 to 0.95) | 12.94(10.09 to 15.78) | 1.21(1.10 to 1.31) | 1.06(0.84 to 1.27) | 12.16(9.46 to 14.85) | 1.26(1.15 to 1.37) |
| Ivermectin – Pyronaridine | 0.95(0.83 to 1.07) | 4.38(3.21 to 5.55) | 1.18(1.11 to 1.25) | 1.22(0.84 to 1.61) | 2.74(1.88 to 3.59) | 1.22(1.11 to 1.34) |
a
All data are reported as mean values (95% confidence interval).