TABLE 3.

Brain region-specific graph-theoretical parameters for stimulus-driven BOLD fMRI.

Significant differences in node parameters expressed as percentage change from Ctr to HNC4-KO (positive percentages indicate an increase in HCN4-KO). A homoscedastic t-test was used as post hoc test for brain regions (p < 0.05; uncorrected). All parameters were tested for both temperatures. Only node parameters that showed significant differences between HCN4-KO and Ctr and within those only significantly different brain regions are shown. For 45°C in particular, the amygdala (light green) showed higher values for HCN4-KO in several parameters. For 50°C, mainly brain stem (blue) and cortical (pink) regions showed differences in the parameter betweenness. Abbreviations: l, left; r, right; ONr, olfactory nuclei; MdVl, ventral medullary reticular nucleus; Gir, gigantocellular reticular nucleus; VTAl, ventral tegmental area; IP, interpeduncular nucleus; SNr, substantia nigra; Mesr, mesencephalic region; thVMl, ventromedial thalamic nucleus; thVlr, ventrolateral thalamic nucleus; thMDl, mediodorsal thalamus; thAr, anterior thalamic group; cxS1HLl, primary somatosensory cortex hind limb; cxS1DZl, primary somatosensory cortex dysgranular; cxS1ULpl, primary somatosensory cortex upper lip; cxPrLr, cxPrLl, prelimbic cortex right and left; cxlLr, infralimbic cortex; cxPdDr, dorsal peduncular cortex; cxOrbl, orbital cortex; cxEntl, entorhinal cortex; cxPrhEctr, perirhinal/ectorhinal cortex; cxPirl, piriform cortex; DBr, nuclei of diagonal band; hcADl, anterior dorsal hippocampus; hcSVl, ventral subiculum; amAr, amAl, anterior amygdala right and left; amMr, amMl, medial amygdaloid nucleus right and left; amBMl, basomedial amygdaloid nucleus; amBLl, basolateral amygdaloid nucleus; amCel, central nucleus of the amygdala; amHAr, amHAl, amygdala hip area right and left; amSLEr, sublenticular extended amygdala; hyPV, periventricular hypothalamic nucleus; AcbCr, core subregion of the nucleus accumbens; AcbShl, shell subregion of the nucleus accumbens; VPr, ventral pallidum; CbVel, cerebellar vermis; CbPVer, CbPVel, cerebellar paravermis right and left; CbDNr, cerebellar deep nuclei.