Fig 6. Pentose phosphate pathway aids in protection to oxygen radicals and cellular killing.

A&B) S. aureus strains were exposed to the indicated chemicals for 4 h before bacteria were enumerated. C) Intracellular survival of strains in macrophages. D) Lysolive assay on macrophages incubated with indicated strains. UN-uninfected, Baf-bafilomycin control. Graphs show means with standard deviation. n = 4 for all except H₂O₂, n = 10. E) Strains were incubated with sytox green before quantifying fluorescence relative to WT. n = 8. F) Congo red viability assays. n = 8. Strains were grown in hydrogen peroxide for 4 h before quantifying bacteria. G) Controls and tar mutant strains. n = 4. Graphs show means with standard deviation. ****P<0.0001, ***P<0.001, **P<0.01.