Skip to main content
. 2023 Jun 25;15(6):e40936. doi: 10.7759/cureus.40936

Table 4. A summary of recent studies describing the treatment regimen used to treat port-site infections.

NTM: Non-tuberculous mycobacteria; PO: Per os (oral); IV: Intravenous

Serial Study, NTM species Treatment Clinical Relapse
1. Ghosh et al. [6], M. abscessus and M. fortuitum Medical treatment based on drug sensitivity No
2. Ramesh et al. [14], M. tuberculosis Surgical debridement + Standard first-line antitubercular regimen; rifampicin, isoniazid, pyrazinamide and ethambutol for 2 mo followed by rifampicin and isoniazid for 9 months No
3. Shah et al. [18], M. fortuitum, M. chelonae Medical treatment only; clarithromycin (PO 6-9 months); ciprofloxacin (PO 6-9 months) No
4. Bhattacharjee et al. [19], 2015; species not specified Medical treatment only; clarithromycin (PO 1-3 months); ciprofloxacin (PO 1-3 months) Persistent skin nodules in 5 cases. Treated with amikacin (local injection 5 days)
5. Chaudhuri et al. [5], 2010 M. fortuitum-chelonae complex Medical treatment only; clarithromycin (PO 1-3 months) and ciprofloxacin (PO 1-3 months) Persistent skin nodules in 7 cases. Treated with amikacin (local injection 5 days)
6. Duarte et al. [20]; 2009, M. bolletii or M. massiliense Surgical debridement + medical treatment; clarithromycin (PO 6 months); amikacin or imipenem or cefoxitin (IV 6 months) No
7. Vijayaraghavan et al. [21]; 2006; M. chelonae Medical treatment only; ciprofloxacin (PO 2-18 months) and amikacin (IV 2-18 months) No
8. Krishnappa and Samarasam [22], 2017, M. chelonae and M. fortuitum Surgical debridement and medical treatment; ciprofloxacin (PO 3 months) OR levofloxacin (PO 3 months) and clarithromycin (PO 3 months) and amikacin (IV 3 months) Recurrence seen in three patients; medical retreatment with the same antibiotics
9. Lahiri et al. [17], 2009, M. fortuitum Surgical debridement + medical treatment; amikacin or imipenem (IV 6 weeks) and ciprofloxacin or clarithromycin (PO 6 weeks) No
10. Muthusami et al. [13], 2004, M. fortuitum Surgical debridement + medical treatment; amikacin (IV 6 weeks-3 months) and ciprofloxacin (PO 6 weeks-3 months) One patient relapsed after 3 months amikacin (IV; 3 months)
11. Samaranayake et al. [23], 2008, NTM Surgical excision of the sinus tract Medical treatment with trimethoprim-sulfamethoxazole (PO 3 months), ciprofloxacin (PO 3 months), and/or amikacin (IV 3 months) No
12. Wright et al. [25], 2014, M. fortuitum and M. abscessus Medical treatment only amikacin, cefoxitin, and imipenem (IV 2-6 weeks); clarithromycin/doxycycline/ minocycline (PO 3-6 months); combination therapy with ciprofloxacin and cotrimoxazole used for M. fortuitum All relapsed - required removal of the device (gastric band)
13. Current study Surgical excision of the sinus tract; medical treatment with clarithromycin (PO 3 months); ciprofloxacin (PO 3 months) No relapse