Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jul 25;2(7):pgad223. doi: 10.1093/pnasnexus/pgad223

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023. Published by Oxford University Press on behalf of National Academy of Sciences.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Fig. 4. — Share of individuals in each cohort whose weekly average vital changes exceeded a specified threshold. A) Share of individuals with more than 5 bpm/day RHR increase. B) Share of individuals with an activity reduction of more than 5,000 steps/day. C) Share of individuals with an increased sleep duration of more than 1 h/day. Red (left), purple (center), and blue (right) bars indicate weekly prevalences for the unvaccinated, vaccinated, and COVID-19 negative cohort, respectively. Error bars indicate the standard error of a binomial distribution. Filled red stars (upper row of significance indicators in each panel) indicate periods where the prevalences in unvaccinated individuals were stronger than for both vaccinated and negative individuals. Hollow red stars indicate periods where the prevalences in unvaccinated individuals were only stronger than that of negative individuals but not of the vaccinated cohort. Purple stars (lower row of significance indicators in each panel) indicate significant differences between vaccinated and COVID-19 negative individuals. All three assessments use a one-sided two proportion z-test with a significance level of $α = 0.01$ . Individuals are considered part of the vaccinated cohort when they received at least two doses of mRNA vaccine.