TABLE 3.
In vivo pharmacokinetic properties of compounds F8 and F8·2HCl.
| Compound | Dose (mg/kg) | Route | AUC (0-∞) (μg/mL*h) | Cmax (μg/mL) | T1/2 (h) | Tmax (h) |
|---|---|---|---|---|---|---|
| F8 | 20 | iv | 6.99 | 12.10 | 3.09 | 0.03 |
| F8 | 100 | ip | 1.13 | 0.40 | 2.66 | 0.19 |
| F8·2HCl | 100 | ip | 1.77 | 0.58 | 3.63 | 1.42 |
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