Table 1.

Trial Site's Main Characteristics

Country	Setting and Sites	Expected Antibiotic Prescription Rate (Based on Historic Prescribing)	Malaria Endemicity and Transmission Patterns	Projected Total Sample Size Over 12 ma	Study Population
Burkina Faso	Rural Pella and Temnaore health centers	77%	Seasonal: high transmission: June to July and October to November	1718	Children and adolescents (6 m to <18 y)
Ghana	Urban, semi-urban Shai-Osudoku District hospital, St. Andrew's Catholic hospital, Pramram District hospital and Ningo health center	43%	Seasonal: July to Octoberb	2766	Children and adolescents (6 m to <18 y)
Uganda	Rural Aduku level IV health center, Nagongera level IV health center Kihihi level IV health center	73%	High, low, and moderate malaria transmission depending on the sitec	2400	Children (>1 y), Adolescents, adults

Both arms, including losses to follow-up.

Malaria season typically runs March to October but varies between ecological seasons. In the Shai-Osudoku area where the study was conducted, the seasons run from May to June and September to November.

Please see the Uganda clinical trial manuscript later in the Supplement for further information (Kapisi J, et al, CID Supplement 2023).