2. Sensitivity analysis for the primary outcome all‐cause mortality up to day 28 for people with moderate to severe COVID‐19.

Outcome	Main analysis using random‐effects model	Main analysis using fixed‐effect model	Risk of bias (excluding studiesa at high risk of bias)
All‐cause mortality up to day 28	RR 0.95, 95% CI 0.85 to 1.05; 3 RCTs, 17,249 participants	RR 0.96, 95% CI 0.90 to 1.02; 3 RCTs, 17,249 participants	RR 1.02, 95% CI 0.63 to 1.62; 2 RCTs, 2357 participants

CI: confidence interval; RCT: randomised controlled trial; RR: risk ratio

^aExcluded study with high risk of bias: Horby 2021 (RECOVERY)