Comparison 1. Individuals with a confirmed diagnosis of COVID‐19 and moderate to severe disease.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1.1 All‐cause mortality up to day 28	3	17249	Risk Ratio (M‐H, Random, 95% CI)	0.95 [0.85, 1.05]
1.2 Worsening up to day 28: participants with new need for invasive mechanical ventilation or death	2	15266	Risk Ratio (M‐H, Random, 95% CI)	0.95 [0.90, 1.01]
1.3 Improvement up to day 28: discharged alive	2	15454	Risk Ratio (M‐H, Random, 95% CI)	1.00 [0.96, 1.04]
1.4 Thrombotic events	4	17518	Risk Ratio (M‐H, Random, 95% CI)	0.90 [0.80, 1.02]
1.5 Serious adverse events	1	1815	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.57 [0.48, 5.14]
1.6 Major bleeding events	4	17527	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.68 [1.29, 2.19]
1.7 Need for new dialysis up to day 28	1	14771	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.99 [0.84, 1.18]
1.8 180‐day mortality	1	1312	Risk Ratio (M‐H, Random, 95% CI)	0.97 [0.82, 1.15]
1.9 All‐cause mortality up to longest follow‐up	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected