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. 2023 Jul 25;2023(7):CD015078. doi: 10.1002/14651858.CD015078

Comparison 2. Subgroup analysis: Effects on mortality up to day 28.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
2.1 Subgroup analysis (type of antiplatelet agent): cyclooxygenase inhibitors or ADP receptor/P2Y12 inhibitors in participants with moderate to severe COVID‐19 3 17249 Risk Ratio (M‐H, Random, 95% CI) 0.95 [0.89, 1.02]
2.1.1 Cyclooxygenase inhibitor (acetylsalicylic acid) 2 15859 Risk Ratio (M‐H, Random, 95% CI) 0.96 [0.90, 1.02]
2.1.2 P2Y12 inhibitor (clopidogrel, ticagrelor, prasugrel) 2 1390 Risk Ratio (M‐H, Random, 95% CI) 1.02 [0.61, 1.69]
2.2 Subgroup analysis: concomitant therapeutic dose anticoagulation or prophylactic anticoagulation 3 15828 Risk Ratio (M‐H, Random, 95% CI) 0.97 [0.83, 1.13]
2.2.1 Antiplatelet agents plus standard care (including prophylactic anticoagulation) 2 15024 Risk Ratio (M‐H, Random, 95% CI) 0.92 [0.77, 1.10]
2.2.2 Antiplatelet agents plus therapeutic anticoagulation 2 804 Risk Ratio (M‐H, Random, 95% CI) 1.27 [0.88, 1.84]