| Horby 2021 (RECOVERY) |
Low risk of bias |
A web‐based randomisation with allocation concealment was used and the baseline characteristics were balanced between groups. |
High risk of bias |
In the intervention group, 10% never obtained the treatment and 31% did not recieve it consistently. There were even 210 (3%) participants in the control group receiving the intervention. |
Low risk of bias |
Data for this outcome were available for 99% of the included participants. |
Low risk of bias |
The measurement of the outcome was appropriate. The decision to start a new renal replacement therapy could have been influenced by the open‐label design, but the influence of the assessment by knowledge of the intervention is almost impossible. |
Low risk of bias |
The SAP was finalized before unblinded outcome data were available, there were no multiple elegible outcome measurements/data for this outcome. |
High risk of bias |
Overall, we rate a high risk of bias due to deviations from the intended intervention. |
