Table 1.

Area under the Curve (AUC) of the Contractile Response Wave of the Internal Anal Sphincter.

	Time after Administration	Control	Hydroxy-α-sanshool (10 mg/body)		Hydroxy-β-sanshool (2.5 mg/body)
		AUC (g-min)	AUC (g-min)	p-value	AUC (g-min)	p-value
10-min segment of the first 1 h	Pre	17±6	10±5	0.669	14±9	0.913
	10 min	115±32	87±15	0.702	220±33	0.064
	20 min	91±58	63±12	0.838	185±32	0.230
	30 min	100±29	72±28	0.786	104±42	0.995
	40 min	47±6	50±7	0.993	85±37	0.418
	50 min	55±13	34±8	0.723	67±34	0.904
	60 min	84±19	30±15	0.255	76±33	0.959
1 h segment	Pre	144±17	97±33	0.552	157±45	0.950
	1 h	493±123	336±32	0.615	736±179	0.356
	2 h	462±147	295±4	0.550	577±149	0.738
	3 h	249±52	240±31	0.997	509±185	0.251
	4 h	210±14	233±4	0.484	220±20	0.862
	5 h	193±69	198±34	0.998	334±74	0.258
	6 h	188±62	175±61	0.987	250±78	0.752

Data are expressed as the mean ± standard error of the mean. n = 3 in each group.

P-values of each treatment group (hydroxy-α-sanshool or hydroxy-β-sanshool) vs control were calculated from Dunnett’s multiple comparison test.