Table 3.

Univariate and Multivariate Analyses of Risk Factors for “eGFR Ratio <0.75 at Three Years” after Rectal Resection (n= 129).

			Univariate			Multivariate
Variables	n	(%)	OR	95% CI	p value	OR	95 % CI	p value
Age
<70 years	86	66.7	1
≥70 years	43	33.3	1.08	0.42–2.79	0.871
Gender
Male	75	58.1	1			1
Female	54	41.9	3.22	1.25–8.28	0.015	4.18	1.34–12.99	0.014
Hypertension
No	86	66.7	1
Yes	43	33.3	0.85	0.32–2.26	0.745
Preoperative CKD (eGFR <60)
No	111	86	1
Yes	18	14	0.54	0.11–2.51	0.428
cT4
No	107	82.9	1			1
Yes	22	17.1	7.92	2.83–22.16	<0.001	5.93	1.1–31.83	0.038
cN+
No	77	59.7	1			1
Yes	52	40.3	2.23	0.9–5.57	0.085	0.94	0.27–3.28	0.921
Neoadjuvant chemotherapy
No	80	62	1			1
Yes	49	38	5.06	1.9–13.46	0.001	3.17	0.84–11.91	0.088
Sphincter preserving surgery
No	35	27.1	1
Yes	94	72.9	1.07	0.38–2.97	0.901
Operative approach
Open	36	27.9	1
Minimally invasive approach	93	72.1	1.49	0.51–4.36	0.469
Lateral lymph node dissection
No	76	58.9	1
Yes	53	41.1	1.73	0.7–4.28	0.236
Combined resection of adjacent organs and/or pelvic plexus
No	117	90.7	1			1
Yes	12	9.3	8.84	2.5–31.25	0.001	0.57	0.07–4.92	0.61
Major complications
No	115	89.1	1
Yes	14	10.9	0.33	0.04–2.62	0.291
Early urinary dysfunction
No	108	83.7	1			1
Yes	21	16.3	3.82	1.35–10.75	0.011	1.89	0.28–12.77	0.513
Early urinary tract infection
No	119	92.2	1
Yes	10	7.8	2.12	0.51–8.91	0.304
Postoperative AKI
No	108	83.7	1
Yes	21	16.3	2.14	0.73–6.3	0.167
Prolonged urinary dysfunction
No	119	92.2	1			1
Yes	10	7.8	3.51	0.9–13.63	0.07	1.91	0.22–16.32	0.555

CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; AKI, acute kidney injury