Table 1.
Patient Characteristics.
| Total (n=2071) | CG (n=875) | DG (n=1196) | p value | |
|---|---|---|---|---|
| Sex (male/female) | 0.14 | |||
| male | 1120 (54.1%) | 490 (56.0%) | 630 (52.7%) | |
| female | 951 (45.9%) | 385 (44.0%) | 566 (47.3%) | |
| Age (years old) (mean, range) | 66 (25 - 94) | 66 (25 - 91) | 66 (28 - 94) | 0.43 |
| BMI† (kg/m2) (mean. range) | 22.35 (12.8 - 39.6) | 22.3 (13.3 - 39.6) | 22.4 (12.8 - 39.6) | 0.27 |
| ASA-PS‡ | 0.31 | |||
| 1-2 | 1760 (85.0%) | 704 (80.5%) | 1056 (88.3%) | |
| 3-6 | 194 (9.4%) | 70 (8.0%) | 124 (10.4%) | |
| Non-epithelial tumor | 12 (0.58%) | 4 (0.46%) | 8 (0.67%) | 0.77 |
| Resected area | 0.067 | |||
| colon | 1113 (53.7%) | 450 (51.4%) | 663 (55.4%) | |
| rectum | 958 (46.3%) | 425 (48.6%) | 533 (44.6%) | |
| Surgical Procedure | <0.0001 | |||
| laparotomy | 646 (31.2%) | 475 (54.3%) | 171 (14.3%) | |
| laparoscopy | 1425 (68.8%) | 400 (45.7%) | 1025 (85.7%) | |
| clinical Stage | 0.29 | |||
| I | 761 (36.7%) | 330 (37.7%) | 431 (36.0%) | |
| II-IV | 1020 (49.3%) | 416 (47.5%) | 604 (50.5%) | |
| Past history | ||||
| smoking | 1182 (57.1%) | 493 (56.3%) | 689 (57.6%) | 0.57 |
| hypertension | 695 (33.6%) | 299 (34.2%) | 396 (33.1%) | 0.64 |
| hyperlipidemia | 153 (7.4%) | 60 (6.9%) | 93 (7.8%) | 0.45 |
| diabetes mellitus | 251 (12.1%) | 115 (13.1%) | 136 (11.4%) | 0.25 |
| pulmonary embolism | 90 (4.3%) | 47 (5.4%) | 43 (3.6%) | 0.063 |
| myocardial infarction | 15 (0.7%) | 5 (0.6%) | 10 (0.8%) | 0.60 |
| heart failure | 64 (3.1%) | 41 (4.7%) | 23 (1.9%) | 0.0004 |
| radiotherapy | 119 (5.7%) | 41 (4.7%) | 78 (6.5%) | 0.085 |
| chemotherapy | 171 (8.3%) | 73 (8.3%) | 98 (8.2%) | 0.94 |
| Preoperative tumor marker (median, range) | ||||
| CEA (ng/ml) | 3.1 (0.5 - 16696.4) | 2.95 (0.5 - 16696.4) | 3.2 (0.5 - 5377.6) | 0.12 |
| CA19-9 (U/ml) | 7 (2 - 100000) | 8 (2-91365) | 6 (2-100000) | 0.75 |
| Preoperative D-dimer (μg/ml) (median, range) | 0.7 (0.1 - 93.2) | 0.7 (0.3 - 43.5) | 0.7 (0.4 - 26.9) | 0.66 |
| Preoperative risk for VTE§ based on Khorana score | 0.28 | |||
| low | 1681 (81.2%) | 720 (82.3%) | 961 (80.4%) | |
| intermediate or high | 390 (18.8%) | 155 (17.7%) | 235 (19.7%) | |
| Preoperative pharmacological thromboprophylaxis | 223 (10.8%) | 86 (9.8%) | 137 (11.5%) | 0.25 |
†BMI, body mass index; ‡ASA-PS, American Society of Anesthesiologists physical status; §VTE, venous thromboembolism