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. 2023 Jul 25;82(4):317–332. doi: 10.1016/j.jacc.2023.05.031

Figure 1.

Figure 1

EAT-Derived miR-92a-3p and Myocardial O2.– Production

(A) Flowchart showing the screening process to identify microRNAs (miRNAs) expressed and released by epicardial adipose tissue (EAT). (B) Heatmap showing the Spearman correlation coefficient between the EAT levels of the 6 identified miRNAs and the basal, nicotinamide adenine dinucleotide phosphate (NADPH)-stimulated, and VAS2870-inhibitable superoxide (O2.–) production in the human myocardium (n = 56). ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, ∗∗∗∗P < 0.0001. (C to E) Basal, NADPH-stimulated, and VAS2870-inhibtable O2.– generation in differentiated H9c2 cardiomyocytes transfected with an miRNA mimic negative control (miR-NC) or miR-30c-5p, miR-92a-3p, and miR-193a-5p mimic (n = 8). Lines on scatterplots represent medians. ∗P < 0.05, ∗∗P < 0.01 vs control by Wilcoxon signed-rank test.