Central Illustration.

EAT miR-92a-3p, Myocardial Redox State, and Clinical Outcomes

Epicardial adipose tissue (EAT) expresses and releases miR-92a-3p that decreases superoxide production in cardiomyocytes possibly by targeting wingless-type MMTV integration site family, member 5a (Wnt5a). Wnt5a induces guanosine triphosphate (GTP) activation of Rac1 that translocates to the cell membrane together with other cytosolic regulatory subunits to form an active enzymatic complex containing nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (eg, NOX2), which catalyzes the production of superoxide (O₂^.–). High EAT miR-92a-3p is associated with lower cardiovascular risk.