Table 1.

Comparisons between a regenerating antler bud and a newt limb blastema

Antler bud	Limb blastema
Potentiated by natural loss of dead antlers, with regeneration activated when sex hormones reach a very low level	Regeneration activated by the accidental loss of distal part of a limb
Flat/concave shape	Round/cone shape
Formed by proliferation and differentiation of the PP cells	Formed by dedifferentiation, transdifferentiation and differentiation of diverse origin limb stump cells
Full thickness of skin heals the wound	Epithelium heals the initial wound
Presence of basal lamina	Absence of basal lamina
Richly vascularized	Avascular
Nerve-independent	Nerve-dependent
Wound epidermis-independent	Wound epidermis-dependent
Wound healing-independent	Wound healing-dependent
Healing with some evidence of a scar	Scar-less wound healing
Dividing cells regionally localized	Dividing cells evenly distributed