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. 2023 Jul 25;13:11984. doi: 10.1038/s41598-023-38230-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(a)–(e) Photomicrographs for histopathological examination of the Hematoxylin & Eosin-stained tongue specimen after induction of OSCC, at week 20, the induction site started to develop epithelial dysplasia (200X) (a). Four weeks later, carcinoma in situ (200X) started to appear on the dorsum surface of the tongue (b). Several mice developed invasive OSCC with some being Grade I (200X) (c) at week 28. Others yield Grade II (200X) (d) at week 32, and some mice developed Grade III (200X) (e) at the end of the induction period after 36 weeks.