Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jul 25;14:4466. doi: 10.1038/s41467-023-40208-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — A Filtering method used to identify high-confidence early-stage and advanced AD protein changes. Proteins that were consistently altered in the same direction in each of the three AD clinical stages were identified (DEPs). Inconsistent proteins within a clinical stage were removed. Preclinical AD and MCI were combined to generate an early AD group. Pie charts specify the number of proteins that are increased/decreased in AD vs controls. Protein changes were filtered to identify high-confidence protein changes in early-stage and advanced AD (altered in ≥5 bulk tissue studies). B GO term (cellular component) network clusters, mapped to show clusters of similar GO terms which were manually annotated to show the overarching cellular component linked to major clusters of GO terms. Each node represents a unique GO term. Node colour shows the proportion of proteins for each enriched GO term that were altered in early-stage AD (blue) and advanced AD (orange). AD Alzheimer’s disease, MCI mild cognitive impairment, DEPs differently expressed proteins.