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. 2023 Jul 25;14:4481. doi: 10.1038/s41467-023-40076-5

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023

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Fig. 2 — a Violin plots of virus titers (pfu/g tissue) in lung and brain of male (squares) and female (circles) mice measured at 3 and 6 dpi. b H&E staining (upper) and in-situ hybridization for SARS-CoV-2 nucleic acid (red) predominantly localizing to pneumocytes in areas of lung inflammation (lower) using serial sections. Scale bars represent 100 μm. Images are representative of lung sections from all CC x K18-hACE2 mice at 3 dpi. c Examples of scoring used to evaluate lung pathology in all biological replicates of CC x K18-hACE2 mice at 3 and 6 dpi. Scale bars represent 500 μm. d Violin plots of lung pathology scores for CC x K18-hACE2 males and females at 3 and 6 dpi. Source data are provided as a Source Data file. The numbers of mice assessed per strain (male: female) were as follows: 3 dpi (K18-hACE2 (5:7); A/J x K18-hACE2 (5:5); PWK x K18-hACE2 (7:6); NZO x K18-hACE2 (7:7); 129S1 x K18-hACE2 (6:5); CAST x K18-hACE2 (8:6); NOD x K18-hACE2 (5:4); WSB x K18-hACE2 (6:9), and 6 dpi (K18-hACE2 (6:6); A/J x K18-hACE2 (6:7); PWK x K18-hACE2 (6:7); NZO x K18-hACE2 (7:5); 129S1 x K18-hACE2 (5:5); CAST x K18-hACE2 (8:9); NOD x K18-hACE2 (4:6); WSB x K18-hACE2 (5:7). Kruskal-Wallis test with Dunn’s posttest was used to compare lung virus titers in each strain/sex to that of K18-hACE2 (males and females separated). *p < 0.05 was considered statistically significant.