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. 2023 Jul 25;14:4481. doi: 10.1038/s41467-023-40076-5

Fig. 4. Spatial transcriptomics reveals differential innate immune responses of pneumocytes, endothelial cells and monocytes in K18-hACE2 and PWK x K18-hACE2 mice.

Fig. 4

10x Genomics Visium spatial transcriptomic analysis of lung sections from K18-hACE2 and PWK x K18-hACE2 at 0 (naïve), 3 and 6 dpi following SARS-CoV-2 inoculation. a, d Confidence scores for cell type annotations based on unsupervised cluster analysis in K18-hACE2 (a) and PWK x K18-hACE2 (d). b, e Bar graph of cell annotations scores in K18-hACE2 (b) and PWK x K18-hACE2 (e). c, f UMAP representation of identified transcriptional clusters in K18-hACE2 (c) and PWK x K18-hACE2 (f).