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. 2023 Jul 25;14:4481. doi: 10.1038/s41467-023-40076-5

Fig. 5. Rapid kinetics of ISG expression associated with virus clearance in PWK x K18-hACE2.

Fig. 5

a Violin plots depicting expression levels of individual ISGs identified in Visium spatial transcriptomics analysis. b In-situ hybridization for SARS-CoV-2 nucleic acid in lung from male K18-hACE2 and PWK x K18-hACE2 mice at 3 and 6 dpi. Scale bars represent 1000 μm; scale bars in insets represent 50 μm. Biological replicates were examined over at least two experiments and 3 male mice/strain/timepoint were randomly selected for assessment of virus distribution by in-situ hybridization. Images are representative of biological replicates.