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. 2023 Jul 25;14:4481. doi: 10.1038/s41467-023-40076-5

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023

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Fig. 6 — Male K18-hACE2 and PWK x K18-hACE2 mice were treated with anti-IFNAR or msIgG1 isotype control 1 day prior to intranasal inoculation with 10⁴ pfu of SARS-CoV-2. a Heatmap of cytokine and chemokine levels in BAL collected at 3 and 6 dpi. b, c Virus titers (pfu/g tissue) in lung (b) and brain (c) at 3 and 6 dpi. Graphs represent virus titers from individual mice (n = 5 mice/timepoint/experimental group) with the mean ± SD. Two-tailed, unpaired Student’s t-test was used to compare virus titers. *p < 0.05 was considered statistically significant. d Percent survival of mice followed daily until 21 dpi. Biological replicates were examined over two independent experiments, the total number of mice per group was as follows: (K18-hACE2, IgG1 n = 11; K18-hACE2, anti-IFNAR1 n = 11; PWK x K18-hACE2, IgG1 n = 14; PWK x K18-hACE2, anti-IFNAR1 n = 14). The Mantel-Cox log-rank test with 95% confidence interval was used to compare survival curves for IgG1- versus anti-IFNAR1-treated groups.