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. 2023 Jul 25;6:775. doi: 10.1038/s42003-023-05143-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a The NFIB expression was determined by IHC in CRC tissue and adjacent normal tissues (n = 261). Representative IHC images of normal mucosa, negative, weak, moderate, and strong NFIB expression are shown. b IHC scores showed overexpression of NFIB in CRC compared with normal colorectal tissues (p < 0.001). c NFIB expression level increased with the TNM stage (p = 0.042). d, e OS and DFS curves of patients with low NFIB protein expression (n = 91) and those with high NFIB protein expression (n = 97). High NFIB expression is associated with poor prognosis (p = 0.0355). f, g OS and DFS curves of patients with high NFIB and NAMPT protein expression. High NFIB and NAMPT levels are associated with poor prognosis (n = 188). Scale bar: 200 μm. IHC immunohistochemical, OS overall survival, DFS disease-free survival. Bar graph data are presented as the mean ± SD; ***P < 0.001.