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. 2023 Jul 25;13:11995. doi: 10.1038/s41598-023-38300-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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CF and nonCF MDM phagocytosis is augmented by CFTR modulators. (A) MDM from CF subjects (n = 7) were treated for 48 h with DMSO or CFTR modulators as indicated. Phagocytosis was measured by gentamicin protection assay. Each line connecting dots represents a single subject, bars represent means of separate experiments. p < 0.001 for DMSO versus TI and p < 0.0001 for DMSO versus ETI. There were no significant differences between bacterial strains, and no interactions between strain and modulators. (B) Identical experiments were carried out with nonCF donors (n = 9). p < 0.01 for DMSO versus TI, p < 0.0001 for DMSO versus ETI. All statistics by mixed effects linear model.