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. 2023 Jul 25;13:11995. doi: 10.1038/s41598-023-38300-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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CFTR triple modulators inhibit MDM mitochondrial function. CF and nonCF MDM were treated for 48 h in vitro with CFTR modulators as in previous experiments. A Seahorse mitostress assay was then performed. (A) Representative mitostress assay with nonCF MDM pretreated with DMSO, TI, or ETI. (B) Basal Respiration of all individual subject MDM tested with and without modulators. Each point with connecting lines represents the mean of technical replicates from an individual subject (CF n = 10, nonCF n = 11). Bars represent means of all the subjects within the group. (C, D) Basal Glycolysis and OCR/ECAR from the same assays as (B).