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. 2023 Jul 25;9(1):44. doi: 10.1038/s41537-023-00369-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The ADRs scores of SNP (rs4149181) alleles in SLC22A8 affected by CYP2D6*10 (rs1065852). Box plot of rs4149181 (AA/GA + GG) and the ADRs scores depending on CYP2D6 polymorphism. The Kruskal‒Wallis test was used for comparisons between groups with Bonferroni correction. In the CYP2D6*10 AA genotype background, the alleles of rs4149181 were significantly different (**P = 0.00143, data are shown as the mean ± SE; AA, 2.53 ± 0.61; GA + GG, 11.71 ± 2.60).